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A Journal on Internal Medicine

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6

Frequency: Quarterly

ISSN 0031-0808

Online ISSN 1827-1898


Panminerva Medica 1998 June;40(2):126-7


Bone den­sity in wom­en ­with endo­me­tri­o­sis

Colacurci N., De Seta L., Passaro M., Scala P., De Franciscis P., Zarcone R.

From ­the Department of Gynecology and Obstetrics, School of Medicine, II University of Naples, Naples, Italy

Objective. To eval­u­ate ­the ­impact of endo­me­tri­o­sis on ­bone metab­olism.
Materials ­and meth­ods. We com­pared ­bone min­er­al den­sity ­and bio­chem­i­cal ­markers (plas­ma oste­o­cal­cin, ­bone alka­line phos­pha­tase, fast­ing uri­nary hydrox­y­pro­line, uri­nary excre­tion of ­cross-­linked N-tel­o­pep­tide of ­type I col­la­gen) of ­bone turn­over in for­ty-­nine per­i­men­o­pau­sal wom­en under­go­ing lap­a­rot­o­my ­because of ­benign gyne­co­log­ic pathol­o­gy: in twen­ty-­four of ­them (­group A) endo­me­tri­o­sis ­was diag­nosed, ­the remain­ing twen­ty-­five rep­re­sent­ed ­the con­trol ­group (group B). Statistical anal­y­sis ­was per­fomed by ­means of Student “t”-­test; sig­nif­i­cance ­was ­set at p<0.05.
Results. Bone den­sity of ­the lum­bar ­spine (0.898±0.325 vs 0.940±0.350) ­and ­bone mark­ers ­failed to ­show sta­tis­ti­cal­ly sig­nif­i­cant dif­fer­enc­es ­between ­the ­two ­groups. No sig­nif­i­cant cor­re­la­tion ­was ­observed ­between ­any ­bone den­sity meas­ure­ment ­and sever­ity of endo­me­tri­o­sis.
Conclusion. Endometriosis ­does ­not ­seem to ­induce ­even in ­advanced stag­es, a reduc­tion of ­bone den­sity.

language: English


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