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Panminerva Medica 1998 March;40(1):41-4

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: English

Preoperative GnRH analogue in hysteroscopic metroplasty

Colacurci N., De Franciscis P., Mollo A., Mele D., Fortunato N., Zarcone R.

From the Department of Gynaecology and Obstetrics School of Medicine Second University of Naples, Naples, Italy


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Objective. To eval­u­ate ­the effec­tive­ness of Gonadotropin-Releasing Hormone ana­logue ­when admin­is­tered pre­op­er­a­tive­ly in hys­ter­os­cop­ic met­ro­plas­ty.
Design. Prospective, com­par­a­tive ­study.
Patients ­and ­main out­come meas­ures. Sixty ­patients under­go­ing hys­ter­os­cop­ic met­ro­plas­ty ­for sep­tate uter­us ­who ­were random­ly allo­cat­ed to pre­treat­ment ­with ­two injec­tions month­ly of Gonadotropin-Releasing Hormone ana­logue or to no pre­treat­ment. To ­assess ­the out­come of sur­gery ­three param­e­ters ­were ­used: oper­a­tive ­time (min­utes), ­fluid adsorp­tion (ml) ­and intra­op­er­a­tive bleed­ing.
Results. No sig­nif­i­cant dif­fer­enc­es in ­the oper­at­ing ­time (21.9 vs 22.9 ­min), ­fluid adsorp­tion (395 ml, ­range 200-550 vs 515 ml, ­range 250-650), intra­op­er­a­tive bleed­ing ­and fail­ure ­rate ­were ­found ­between pre­treat­ed ­patients ­and con­trols.
Conclusions. Preoperative treat­ment ­with Gonadotropin-Releasing Hormone ana­logue ­showed no advan­tage in hys­ter­os­cop­ic treat­ment of mul­ler­ian ­defects, ­but ­only an improve­ment, ­not sta­tis­ti­cal­ly sig­nif­i­cant, in ­term of ­reduced oper­a­tive ­time ­and ­fluid adsorp­tion.

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