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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery
Indexed/Abstracted in: EMBASE, Scopus
COCHLEAR IMPLANTS AND OTHER IMPLANTABLE AUDITORY
Otorinolaringologia 2014 December;64(4):163-6
Nanoparticles as a drug-delivery vehicle for the inner ear
Kim M.-S., Kim D.-K.
Department of Otolaryngology, Head and Neck Surgery, Catholic University of Korea, College of Medicine, Seoul, Republic of Korea
Hearing loss is a common sequela to many inner ear disorders. However, the therapeutic options for these conditions are limited as the inner ear is inaccessible to many drugs. Theoretically, nanoparticles that permeate the round window can target specific cell populations and provide controlled drug release. Nanoparticles have shown promise as an inner ear drug delivery vehicle in many reports. Toxicity, especially with long-term use, should be determined prior to clinical use. Also, the drug to nanoparticle loading ratio should be increased to maximize the delivery efficacy and minimize toxic effects. Understanding of the RW, including the mechanism of passage, should be expanded.