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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery

Indexed/Abstracted in: EMBASE, Scopus




Otorinolaringologia 2010 December;60(4):221-32

language: English, Italian

Rationale for the use of hyaluronic acid in nasal spray after nasal septal surgery: a controlled clinical study

Di Lieto C., Ceroni Compadretti G., Tasca I.

ENT Department, Castel San Pietro Terme Hospital, Imola, Bologna, Italy


Aim. The purpose of this study was to assess the effectiveness of a nasal spray (Ialoclean®) containing hyaluronic acid in the treatment of symptoms following functional nasal septum surgery.
Methods. The study group was 159 patients who underwent functional nasal septum surgery: 100 applied Ialoclean® nasal spray for 30 days (treatment group), the remaining 59 did not (control group). Postoperative assessment was based on two sets of criteria: patient symptom scores and clinical endoscopic examination. Both data sets were collected at assessment 1 week and 1 month after discharge.
Results. On assessment one week after discharge, symptom scores (nose-blowing frequency, mucus in throat, mucopurulent rhinorrhea, crust formation, nasal dryness, and nasal obstruction) were lower for the treatment group than the controls; endoscopic examination revealed less nasal congestion, secretion retention and crust formation in the treatment group. On assessment at one month, the results for the two groups were substantially similar, except for the occurrence of nasal dryness and crust formation which was more frequent in the controls.
Conclusion. In our experience, the use of Ialoclean® nasal spray following functional nasal septum surgery helps to maintain nasal cavities patency by eliminating mucus, reduce nasal dryness and crust formation, accelerate cicatrization and promote healing.

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