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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery
Indexed/Abstracted in: EMBASE, Scopus
INTRATYMPANIC THERAPIES FOR INNER EAR DISORDERS
Otorinolaringologia 2010 September;60(3):141-3
Pharmacokinetics of drugs in transtympanic administration
Dispenza F., Kulamarva G., De Stefano A.
1 Department of Surgical and Oncological Disciplines, University of Palermo, Palermo, Italy
2 ENT Clinic, Nayak’s Road, Kasaragod, Kerala, India
3 ENT Institute, Department of Surgical, Clinical and Experimental Sciences, “G. d’Annunzio” University of Chieti and Pescara, Chieti, Italy
There are two possible ways to deliver drugs in cases of inner ear diseases: via the bloodstream through systemic administration and through the two windows of the inner ear by application into the middle ear cleft. Efforts to find the strategies to deliver drugs to the inner ear are continuously made by Researchers worldwide. This brief description of inner ear will show the fate of drugs after transtympanic administration, discussing the anatomic and physiologic key point to understand the inner ear pharmacokinetics.