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CURRENT ISSUEOTORINOLARINGOLOGIA

A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery

Indexed/Abstracted in: EMBASE, Scopus

Frequency: Quarterly

ISSN 0026-4938

Online ISSN 1827-188X

 

Otorinolaringologia 2010 September;60(3):141-3

INTRATYMPANIC THERAPIES FOR INNER EAR DISORDERS 

Pharmacokinetics of drugs in transtympanic administration

Dispenza F., Kulamarva G., De Stefano A.

1 Department of Surgical and Oncological Disciplines, University of Palermo, Palermo, Italy
2 ENT Clinic, Nayak’s Road, Kasaragod, Kerala, India
3 ENT Institute, Department of Surgical, Clinical and Experimental Sciences, “G. d’Annunzio” University of Chieti and Pescara, Chieti, Italy

There are two possible ways to deliver drugs in cases of inner ear diseases: via the bloodstream through systemic administration and through the two windows of the inner ear by application into the middle ear cleft. Efforts to find the strategies to deliver drugs to the inner ear are continuously made by Researchers worldwide. This brief description of inner ear will show the fate of drugs after transtympanic administration, discussing the anatomic and physiologic key point to understand the inner ear pharmacokinetics.

language: English


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