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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery

Indexed/Abstracted in: EMBASE, Scopus




Otorinolaringologia 2010 March;60(1):11-3

language: Italian

Use of a compound containing N-acetyl-cysteine, echinacea, uncaria and propoles in antibiotic therapy for upper respiratory infections

Beatrice F., Bucolo S.

Struttura Complessa di Otorinolaringoiatria, Ospedale San Giovanni Bosco, ASL TO2, Torino, Italia


The study compares two treatment approaches to upper respiratory infections as measured by patient self-report of changes in symptoms. The study population was divided into two homogeneous groups (age range, 18-25 years) and administered amoxicillin clavulanate, a commonly used antibiotic for such infections. One group received adjuvant antibiotic therapy with Prodefens, a compound containing N-acetyl-cysteine, echinacea, propolis and uncaria. The patients self-evaluated changes in 7 characteristic symptoms of upper respiratory infections on a 5-point Likert scale. As compared with the group given amoxicillin clavulanate alone, a significant reduction in symptom severity and duration was observed in the group that had received adjuvant antibiotic therapy with Prodefens. These preliminary results need to be substantiated with further studies on the therapeutic efficacy of combination therapy with Prodefens in the treatment of upper respiratory infections, given the increasing risk of bacterial resistance to widely used antibiotics.

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