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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery
Indexed/Abstracted in: EMBASE, Scopus
Otorinolaringologia 2009 June;59(2):71-3
GLUT-3 expression in laryngeal carcinoma: is really a prognostic indicator?
Dispenza F. 1,2, Saraniti C. 2, Cabibi D. 3, Gallina S. 2, Incandela C. 2, Dispenza C. 2
1 Department of Surgical and Oncological Disciplines University of Palermo, Palermo, Italy
2 Operative Unit of Otolaringology University of Palermo, Palermo, Italy
3 Department of Human Pathology University of Palermo, Palermo, Italy
Aim. We describe our experience about cellular membrane glucose transporters (GLUT) as prognostic factors in laryngeal cancer through a retrospective evaluation of presence of GLUT 1-3 in specimens of squamocellular cancer of larynx
Methods. We assessed the expression of GLUT1 and GLUT3 in 50 formalin fixed, paraffin embedded biopsy specimens of laryngeal carcinoma. The antibodies used were anti-GLUT1 MYM and anti-GLUT3 MYG. Specimens were considered positive only when strong membrane-associated immunoreactivity was observed. Positive controls for MYM were erythrocytes present in each section, and for MYG were sections of human testis.
Results. Strong positive result for GLUT1 on 100% of cases and no positive issue for GLUT3.
Conclusion. Our results indicate that GLUT-3 is not useful as prognostic factor in this kind of tumor.