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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery

Indexed/Abstracted in: EMBASE, Scopus




Otorinolaringologia 2008 June;58(2):119-23

language: English

Primitive lymphoepithelial carcinoma of parotid gland. Case report

Taglia C., Matteini C., Carboni A., Perugini M., Cerulli G.

Department of Maxillo-Facial Surgery Belcolle Hospital ASL Viterbo, Viterbo, Italy


Lymphoepithelial carcinomas present a double histological components, epithelial and stromal. Such carcinoma typically affects nasopharinx, is significantly associated with specific racial origins and is usually correlated with Epstein-Barr virus infections. The salivary glands can be interested by distant metastases of nasopharyngeal carcinoma even if skeletal sites are more usually affected, but primary lymphoepithelial carcinomas of the salivary gland is a very rare event in clinical practice. In the author’s report a 48-year-old Caucasian female patient presented with a neoplasm of the left parotid. After parotidectomy the histological diagnosis was lymphoepithelial carcinoma. Due to the rarity of such neoplasm of parotid gland, the patient underwent a careful clinical evaluation to detect a possible primitive rhinopharingeal malignancy, such as lymphoepithelioma. Nuclear magnetic resonance imaging to study rhinopharinx, and total body computed tomography scan were performed, as well as a second surgical operation to achieve multiple biopsies of pharynx under endoscopic guide. Any suspicious image was evident and no pathologic tissue was found in the tissues series bioptised. In the mean time the research for Epstein-Barr virus antibodies on the specimen gave a negative result. Definitive diagnosis, even if rare, was primary lymphoepithelial carcinoma of the salivary gland.

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