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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery

Indexed/Abstracted in: EMBASE, Scopus




Otorinolaringologia 2008 June;58(2):93-106


language: Italian

Topical use of ciprofloxacin in acute otitis externa (AOE) study on the indications of Clinical Practice Guideline: acute otitis externa

Marzullo C.

Servizio di Otorinolaringoiatra ASL RM/D - RM/H, Roma, Italia


The aim of the present study was to analyse the diffuse non-complicated acute otitis externa (AOE) treated according to the indications of the Clinical Practice Guideline acute otitis externa published in 2006. During a period of 12 months clinical cases of AOE in Senturia class 2 (patients ranging from 2 to 90 years old) have been compared with controlled groups, randomized into normal population and subjects at dermatologic-dismetabolic risk. An initial topical therapy has been used, which included, as indicated in the protocol, the use of an anti-microbic otologic suspension, used with ciprofloxacin (Mediflox). This substance is also indicated as a therapeutic substitute to be used as a first choice, to avoid the use of potentially ototoxic substances in patients affected by AOE and/or are supposed to have a suspected/non-diagnosed perforation of the eardrum. The review analyzes 191 cases with a personal protocol of diagnosis/treatment, having as a final target in binary outcome the eradication of all bacteria (bacteriologic cure vs failure). After a 5-day observation, 89% of diffused non-complicated AOE had been cured. The remaining clinical microbiologic cases demonstrated a complete bacteriologic eradication (100%) after a 10-day treatment. After the first step (5-day treatment) the rate of bacteriologic eradication rises to 92.1%, if considering the cases of AOE with otomicosis that were excluded because of a different outcome.

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