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Indexed/Abstracted in: EMBASE, Scopus
Online ISSN 1827-188X
Kleinjan A., Lambrecht B. N.
Department of Pulmonary Medicine Erasmus MC Rotterdam, The Netherlands
In the last decades there has been an enormous interest of immunologists in the role that antigen-presenting dendritic cells (DC) play in induction and regulation of immune responses. DC sample the outside world for incoming antigen and present it to the various players of the immune system so that an optimal response is induced to clear pathogens. Current knowledge of the basic aspects of DC function is recently integrated in the framework of disease pathogenesis. DCs have been implicated in causing allergic sensitization as well as ongoing allergic inflammation. In this review we focus on the role of DCs in allergic rhinitis.