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Indexed/Abstracted in: EMBASE, Scopus
Online ISSN 1827-188X
Salami A. 1, Medicina M. C. 1, Dellepiane M. 1, Mura A. C. 2
1 Clinica Otorinolaringoiatrica 2 Università degli Studi di Genova, Genova
2 Struttura Complessa di Otorinolaringoiatria Ospedale Galliera, Genova
Epithelial-myoepithelial carcinoma is approximately 1% of all salivary glands tumors. It usually arises in the parotid gland, but it can also occur in the minor ubiquitous salivary glands. Histological and biological features are at present a controversial matter. Biological feature is not univocal: the epithelial-myoepithelial carcinoma is benign in the majority of cases, but local recurrence, cervical lymph-node metastases and distant metastases at interval from 2 months to 28 years have been described. In this paper 3 cases of epithelial-myoepithelial carcinoma are presented, 2 of the parotid gland and 1 of a minor salivary gland of gingiva. As regard clinical signs, the most important was a mass in the primary and/or metastatic site, increasing in size from 6 months to 1 year. In the cases of the parotid area, there was not facial asymmetry or pain. In case 1, neck node metastases at the diagnosis were present and systemic metastases within 1 year were observed; in case 3, multiple primary site recurrences within 2 years after initial surgery were observed and a total parotidectomy was performed. Case 2 showed extension to the surrounding tissue and to the neck nodes; cutaneous local recurrences were found and a postoperative radiotherapy and chemotherapy were administered. On the basis of our case series and in agreement with other authors, it is possible to confirm that the association between clinical staging and other factors showing the stage of carcinoma differentiation, like myoepithelial markers or cell proliferative activity, contribute to reveal the biological behaviour of the neoplasm and its therapy.