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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery
Indexed/Abstracted in: EMBASE, Scopus
Otorinolaringologia 2004 March;54(1):41-5
Prevalence of CD30 positive reactive subepithelial lymphocytes in tonsillar biopsies from patients affected by infectious mononucleosis over chronic recurrent tonsillitis
Tamiolakis D. 1, Arvanitidou V. 2, Thomaidis V. 3, Tsamis J. 4, Jivannakis T. 5, Kotini A. 6, Papadopoulos N. 5
1 Departments of Cytology, Regional Hospital Alexandroupolis, Greece
2 Department of Pediatrics, Democritus University of Thrace Alexandroupolis, Greece
3 Department of Maxillofacial Surgery, Regional Hospital Alexandroupolis, Greece
4 Department of Pathology, General Hospital, Drama, Greece
5 Department of Histology-Embryology Democritus University of Thrace, Alexandroupolis, Greece
6 Department of Medical Physics Democritus University of Thrace, Alexandroupolis, Greece
Aim. CD30 (Ber-H2) antigen has been considered to be expressed on hematopoietic cells including the ones of the recently described anaplastic large cell lymphoma (ALCL), the Reed-Sternberg (RS) cells of Hodgkin’s disease and scattered large parafollicular cells in normal lymphoid tissues. Since then, several reports have been published describing CD30 expression in non-hematopoietic and malignant cells, such as cultivated human macrophages, human decidual cells, histiocytic neoplastic cells, mesothelioma cells, embryonal carcinoma, and seminoma cells. Infectious mononucleosis results from primary infection with Epstein-Barr virus (EBV) and is a common cause of lymphadenopathy which may mimic malignant lymphoma. Tonsils from patients with acute infectious mononucleosis show a prominent immunoblastic proliferation coupled with Reed-Sternberg-like cells and a polymorphous inflammatory cell background. Chronic tonsillitis is a term used by many pathologists in referring in lymphoid hyperplasia of surgically removed tonsils. Lack of perceptible factors of differentiation between the 2 entities encouraged us to study the lymphocytic subpopulations in tonsillar biopsy specimens obtained from patients with lymphadenopathy EBV positive and EBV negative.
Methods. Tonsils were biopsied in 12 unequivocal cases of atypical clinical findings and a negative heterophil antibody test at admission in our clinic. In the process the test was repeated and turned to positive in 6 cases while negative values were observed again in the remaining 6 patients. In all 12 cases we investigated the subepithelial tonsillar lymphocytic subsets by means of CD30, CD45RO and CD20 antigens expression.
Results. A statistically significant predominance (p<0.001, “t”-test) in CD30 positive cells in the cases of infectious mononucleosis over chronic recurrent tonsillitis was discovered.
Conclusion. We suggest that an increase in CD30 might be connected with stronger expression of EBV nuclear antigen on immunoblasts.