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Indexed/Abstracted in: EMBASE, Scopus
Online ISSN 1827-188X
Laboratory of Microbiology CHU Bichat-Claude Bernard, Paris, France
Acute rhinosinusitis is one of the most common causes of acute and chronic infections seen in the community. The initial viral infection can be followed by a bacterial superinfection which can be demonstrated using specific investigations such as bacterial isolation. In the great majority of cases the diagnosis is presumptive. Symptomatic treatments tend to reduce pain and inflammation for easier pus drainage. The decision for antibiotic therapy continues to be a matter of debate. Many antibiotics have been used, but modern guidelines have established recommendations for the choice and duration of treatments, based on: 1) epidemiological data on pathogens and their resistance profile; 2) improved understanding of pharmacology of antibiotics, guiding doses and administration routes; 3) comparative double blind studies, evaluating antibiotics vs placebo, β-lactams vs macrolides. Use of newer drugs (fluoroquinolones, ketolides) must be discussed in terms of cost/efficacy.