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Indexed/Abstracted in: EMBASE, Scopus
Online ISSN 1827-188X
Aversa S. 1, Guerrasio A. 2, Ondolo C. 1, Fadda G. L. 1, Conticello S. 1
1 Department of Otolaryngology
2 Department of Medicine University of Turin, Turin
MALT lymphoma describes a group of non-Hodgkin’s lymphomas that includes extranodal primary malignant B-cell tumors and low-grade malignant tumors, with characteristic mucosa-associated lymphoid tissue (MALT). Low-grade MALT lymphomas are generally slow growing and tend to remain localized for prolonged periods. Prognosticaly, the survival rates are good, with a higher tendency for local recurrence rather than for widespread distant disease. In the salivary glands, the tumors arise in a background of myoepithelial sialadenitis (MESA), usually in association with Sjögren’s syndrome (SS). Tumor cytomorphology and histology, coupled with immunophenotypic and genotypic features in a clinical context, suggest the diagnosis of low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Two cases of MALT lymphoma of the parotid glands are presented because of the rarity of the disease. In addition, we describe current guidelines for a correct diagnostic approach based on histopathologic studies and diagnostic imaging, and surgical treatment followed by radiotherapy and/or chemotherapy. Also, recent data from the literature on genetic alterations related to tumor diagnosis are reported.