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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery
Indexed/Abstracted in: EMBASE, Scopus
Otorinolaringologia 2001 December;51(4):155-8
Neuroendocrine laryngeal neoplasm. A report of two cases
Saraniti C., Caramanna C., Miceli L. *, Dispenza C.
Università degli Studi - Palermo Istituto di Clinica Otorinolaringoiatrica «R»
*Istituto di Anatomia ed Istologia Patologica
Neuroendocrine tumours are rare and aggressive neoplasms. The most accredited hypothesis is that they derive from cells of the diffuse neuroendocrine system (APUD). They show a preference for males and heavy smokers; the peak incidence is found between the sixth and seventh decade of life. The authors present two cases observed between 1999 and 2000: a case of atypical carcinoid or moderately differentiated neuroendocrine tumour and a case of small cell carcinoma or poorly differentiated neuroendocrine tumour. The CT image of the latter is shown. The authors discuss the histological characteristics of these tumours, the importance of their innnunohistochemical study which allows a ready differentiated diagnosis compared to other histotypes, such as the laryngeal paraganglioma, melanoma and squamous carcinoma ofthe larynx for the atypical carcinoid; malignant lymphoma and epidermoid small cell carcinoma for the small cell carcinoma. Treatment is surgical for the atypical carcinoid, whereas chemo- and radiotherapy are used for the oat cell carcinoma. The 5-year survival rate is 48% for atypical carcinoid and 5% for small cell carcinoma.