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Indexed/Abstracted in: EMBASE, Scopus
Online ISSN 1827-188X
Università degli Studi - Torino Dipartimento di Medicina Interna Cattedra di Gastroenterologia (Direttore: Prof. M. Rizzetto)
Gastroesophageal reflux disease (GERD) occurs with high prevalence in the general population. Moreover GERD is particularly prevalent in patients with respiratory pathologies and other extra-esophageal disorders. Studies have focused on laryngeal manifestations, such as aphonia, laryngitis, cough, laryngeal stenosis and cancer and a causal relationship has been postulated by many investigators. Other investigators demonstrated an association of GERD with sinusitis and pharyngitis. However, despite the improvements in non-malignant types, after antisecretory high-doses drugs assumption, the pathogenetic mechanism, a vagally mediated reflex or microaspiration, is unclear. Further research is needed to clarify what role GERD has on the pathogenesis and wheter a medical or surgical anti-secretory treatment is a possible approach for the patients non-responder to the classical therapy. It be prudent to look for GERD in patients with laryngeal diseases in whom no other aetiology exists.