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Otorinolaringologia 1999 December;49(4):157-8

language: English

Pirenzepine inhibition of transient evoked otoacoustic emissions

Abidi Mousavi A., Ottaviani F., Ugazio G.*, Procopio M. T.*, Cerati E.*, Melis O., Santini M.*, Ottaviani A.

From the Department of Otological Sciences and
* Department of Pharmachology University of Milan, Milan


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Back­ground. It has ­been pre­vi­ous­ly report­ed by ­this labor­a­to­ry ­that the M1 and M2 mus­ca­rin­ic block­er, piren­ze­pine, in- hib­its in ­humans tran­sient-­evoked otoa­cous­tic emis­sions (TEOAEs).
Meth­ods. The guin­ea ­pigs ­have now ­been ­used to ­extend to ­this ani­mal spe­cies the ­above ­data ­along ­with a pros­pec­tive, ­more com­pre­hen­sive and ­detailed phar­mac­o­log­i­cal dis­sec­tion of ­TEOAEs ­than ­allowed in the ­human ­being.
­Results. Piren­ze­pine has ­shown to inhib­it ­TEOAEs, ­thus extend­ing to guin­ea ­pigs the ­human ­data.
Con­clu­sions. The ­present ­results of an excit­a­to­ry chol­i­ner­gic mech­a­nism on ­TEOAEs vis a vis ­adverse the inhib­i­to­ry sym­pa­thet­ic one, ­while extend­ing the coch­le­ar chol­i­ner­gic effer­ents to the sym­pa­thet­ic-sen­so­ry ­coupling pro­gramme of an ubiq­ui­tous­ly per­va­sive ton­ic sym­pa­thet­ic inhi­bi­tion on periph­er­al sen­so­ry struc­tures.

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