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A Journal on Otorhinolaryngology, Head and Neck Surgery,
Plastic Reconstructive Surgery, Otoneurosurgery
Indexed/Abstracted in: EMBASE, Scopus
Otorinolaringologia 1999 March;49(1):47-51
Sulfurous chrenotherapy in the treatment of sino-nasal polyposis. Influence of secretory IgA
Bussi M., Majore L., Cardarelli L., Napoli P.*, Riontino E., Albera R., Battaglio S.*
Università degli Studi - Torino Dipartimento di Fisiopatologia Clinica Sezione ORL II
* Dipartimento di Medicina e Oncologia Sperimentale Sezione Ematologia
Background and aims. Inflammatory pathology and allergic and hyperergic manifestations in the upper airways are a widespread and steadily increasing phenomenon. The main immune defence against infections and antigenic immunoexclusion at the level of mucosa is locally produced and SIgA mediated. Experience document the existence of SIgA deficits in a number of ENT pathology. This is countered by the positive effect of chrenotherapy on these disorders. The therapeutic effects of sulfureus chrenotherapy may partly be ascribed to increased SIgA levels. This study aimed to use sulfureus chrenotherapy not in the treatment of macropolyposis (the elective management of this pathology is still surgery), but in the prophylaxis of postsurgical recidivations of so-called “inflammatory” polyps.
Methods. While waiting for surgery, 30 patients with non-allergic polyposis underwent a cycle of endonarinal lavages for 21 days whit sulfurous water (15 patients) or saline solution (15 patients). Nasal secretions were collected using a modified washing method at the basal control and at the end of treatment and SIgA assay was performed using a personal method of ImmunoIsoElectrofocusing.
Results. Basal controls showed 29/30 patients with lower SIgA levels compared to laboratory internal standards. At the end of treatment, a mean increase was noted in SIgA levels which was, as expected, higher in the group treated with sulphurous water.
Conclusions. The authors feel it is useful to underline that the indications for sulphurous chrenotherapy, as a support treatment for the most commonplace ENT disorders, deserve re-evaluation by doctors owing to the proven positive effects of treatment and the virtual absence of contraindications and collateral effects.