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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2016 Nov 30

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Prognostic value of interim FDG PET-CT in patients older than 60 years with diffuse large B-cell lymphoma treated by PMitCEBO plus Rituximab: comparison between Deauville 5-point scale and International Harmonization Project criteria

Naelle LOMBION 1, Philippe ROBIN 2, Adrian TEMPESCUL 1, Pierre-Yves LE ROUX 2, Ulrike SCHICK 3, Gaëlle GUILLERM 1, Jean C. IANOTTO 1, Christian BERTHOU 1, Pierre Y. SALAÜN 2, Ronan ABGRAL 2

1 Department of Haematology, University Hospital of Brest, Brest, France; 2 Department of Nuclear Medicine, University Hospital of Brest, Brest, France; 3 Department of Oncology-Radiotherapy, University Hospital of Brest, Brest, France


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BACKGROUND: Advanced age is an independent poor prognostic factor of diffuse large B-cell lymphoma. PMitCEBO is an alternative to CHOP to decrease side effects in elderly patients. Many studies have shown prognostic value of an interim FDG PET-CT to predict survival. A recent consensus (ICML, Lugano 2013) has suggested using the 5-point scale Deauville criteria instead of those of the international harmonization project (IHP) to visually assess the response on interim PET. The objective of this study was to evaluate the prognostic value of an interim FDG PET-CT in patients older than 60 with treated DLBCL and to compare IHP and 5-PS Deauville visual interpretation to predict survival.
METHODS: Forty-eight patients (mean age 73.2±5.2 years) treated by R- PMitCEBO for DLBCL undergoing FDG PET-CT before and after 3 cycles of treatment were retrospectively included. Event-free survival and overall survival were determined by Kaplan Meier method and compared with interim PET-CT results using IHP and 5-PS Deauville criteria.
RESULTS: Interim PET results using 5-PS Deauville criteria were significantly correlated with EFS (p<0.0001) and OS (p=0.001) whereas they were moderately correlated with EFS (p=0.046) and not with OS (p=0.106) using IHP criteria. The 2-years EFS and OS rates were respectively 86.5% and 89.2% for patients in 1-3 score group and 27.3% and 36.4% for patients in ≥ 4 score group using Deauville criteria.
CONCLUSIONS: Our results confirmed the prognostic value of an interim PET- CT in elderly patients with DLBCL and the better performance of the 5-PS Deauville criteria.

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Lombion N, Robin P, Tempescul A, Le Roux PY, Schick U, Guillerm G, et al. Prognostic value of interim FDG PET-CT in patients older than 60 years with diffuse large B-cell lymphoma treated by PMitCEBO plus Rituximab: comparison between Deauville 5-point scale and International Harmonization Project criteria. Q J Nucl Med Mol Imaging 2016 Nov 30. 

Corresponding author e-mail

ronan.abgral@gmail.com