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A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
Luigi AULETTA 1, Matteo GRAMANZINI 2, 3, Sara GARGIULO 2, 3, Sandra ALBANESE 3, 4, Marco SALVATORE 1, Adelaide GRECO 2, 3, 4
1 IRCCS SDN, Napoli, Italy; 2 Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy; 3 CEINGE Biotecnologie Avanzate, Scarl, Napoli, Italy; 4 Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli Federico II, Napoli, Italy
INTRODUCTION: Preclinical molecular imaging is an emerging field. Improving the ability of scientists to study the molecular basis of human pathology in animals is of the utmost importance for future advances in all fields of human medicine. Moreover, the possibility of developing new imaging techniques or of implementing old ones adapted to the clinic is a significant area.
EVIDENCE ACQUISITION: Cardiology, neurology, immunology and oncology have all been studied with preclinical molecular imaging. The functional techniques photoacoustic imaging (PAI), fluorescence molecular tomography (FMT), photon emitting tomography (PET), and single photon emitting computed tomography (SPECT) in association with each other or with the anatomic reference provided by computed tomography (CT) as well as with anatomic and functional information provided by magnetic resonance (MR) have all been proficiently applied to animal models of human disease.
EVIDENCE SYNTHESIS: All the above-mentioned imaging techniques have shown their ability to explore the molecular mechanisms involved in animal models of disease. The clinical translatability of most of the techniques motivates the ongoing study of their possible fields of application.
CONCLUSIONS: The ability to combine two or more techniques allows obtaining as much information as possible on the molecular processes involved in pathologies, reducing the number of animals necessary in each experiment. Merging molecular probes compatible with various imaging technique will further expand the capability to achieve the best results.