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A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
Online ISSN 1827-1936
Karaca S. 1, Rager O. 2, Kalangos A. 1
1 Service of Cardiovascular Surgery, University Hospital Geneva, CH-1211 Geneva, Switzerland
2 Service of Nuclear Medicine, University Hospital Geneva, CH-1211 Geneva, Switzerland
OBJECTIVE: We sought to evaluate the potential role of positron emission tomography–computed tomography (PET–CT) for the detection and diagnosis of potential infections of vascular grafts using combining metabolic (i.e., radioactive fluorine-fluoro-D-deoxyglucose (18F-FDG)) PET with morphological (CT) information and investigate long-term capability.
METHODS: Seventeen patients with suspected vascular-graft infection underwent thoracic–abdominal–pelvic FDG PET combined with contrast-enhanced CT using a hybrid PET–CT scanner providing co-registered PET and CT images.
RESULTS: In this retrospect study, we suspected graft infection in 14 of 17 patients detected using PET–CT and increased the maximal uptake of 18F-FDG around the grafts. Other vascular localisations were not observed. All patients with positive PET–CT results underwent redo-surgery, and the infection was ultimately confirmed using microbiological testing in 12 of 14 patients. Follow-up time was median of 58 months (range 36-73 months) for all 17 patients. In these patients, there was no further evidence of graft infection found on clinical and imaging follow-up.
CONCLUSION: This is first investigation presenting long-term follow-up, which confirmed that 18F-FDG-PET/CT is an excellent diagnostic modality for suspected vascular graft infection. 18F-FDG PET-CT exhibited a sensitivity of 100% and specificity of 71.4% for the detection of vascular-graft infection.