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A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
Online ISSN 1827-1936
Hojjat AHMADZADEHFAR 1, Torsten HINZ 2, Anja WIERZBICKI 1, Tobias HÖLLER 3, Elham HABIBI 1, Jörg WENZEL 2, Marianne MUCKLE 1, Hans J. BIERSACK 1, Markus ESSLER 1, Monika SCHMID-WENDTNER 4
1 Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany; 2 Department of Dermatology and Allergology, University Hospital Bonn, Bonn, Germany; 3 Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany; 4 Interdisciplinary Oncology Center (IOZ), Munich, Germany
BACKGROUND: Assessing whether an association exists between drainage to multiple basins and lymphatic metastasis in patients with truncal melanoma (TM).
METHODS: The study included 260 patients with primary TM (163 men; median age 56.5 y/o) with a cN0 M0, who underwent a sentinel lymph node scintigraphy and biopsy. The median tumor thickness (TT) was 1.51 mm.
RESULTS: One hundred and three patients showed more than one basin; of these, 95 patients had 2 basins, 6 had 3 basins, and 2 had 4 basins of drainage. Nodal histology was positive for metastatic disease in 65 patients, of whom, 40 had 1 basin, 24 had 2 basins and 1 had 3 basins of drainage. Of the 195 node-negative patients, 116 had 1 basin, 70 had 2 basins, 5 had 3 basins, and 2 had 4 basins of drainage (P=0.89). In a median follow-up of 36 months, 26 patients showed progressive disease, of whom 15 had 1 basin and 11 had 2 basins (P=0.76). Twenty patients died, of whom 11 had 1 basin and 9 had 2 basins (P=0.8).
CONCLUSIONS: There is no significant association between the number of drainage basins and sentinel node positivity or further progress of the disease in patients with TM.