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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2014 September;58(3):237-57

language: English

Imaging T-lymphocytes in inflammatory diseases: a nuclear medicine approach

Malviya G. 1, Galli F. 2, Sonni I. 2, Signore A. 2

1 Beatson Advanced Imaging Resource (BAIR), Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, UK;
2 Nuclear Medicine Unit, Faculty of Medicine and Psychology, “Sapienza” University, Rome, Italy


FULL TEXT  


Increasing interest and research efforts have been made in search of specific radiolabelled probes for imaging different immune cells (including T-lymphocytes) in inflammation and infection. This has led to early detection of lymphocyte infiltration, and the deepening of our understanding of pathogenesis of immune mediated diseases. In-vivo imaging of T-lymphocytes with radiolabelled specific probes may provide an important piece of information about inflammatory lesions, which could be very important to understand the molecular mechanism of action of any drug and/or their effect on the microenvironment of the immune system of the body. The present review focuses on radiolabelled T-lymphocytes and different monoclonal antibodies, peptides, cytokines, chemokine used for scintigraphic imaging of T-lymphocytes and their subsets.

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g.malviya@beatson.gla.ac.uk