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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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The Quarterly Journal of Nuclear Medicine and Molecular imaging 2010 June;54(3):281-90

language: English

PET imaging of the immune system: immune monitoring at the whole body level

Singh A. S. 1, Radu C. G. 2,3, Ribas A. 1,3,4

1 Division of Hematology/Oncology, Department of Medicine, University of California (UCLA), Los Angeles, CA, USA;
2 Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging UCLA, Los Angeles, CA, USA;
3 Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA, USA;
4 Broad Stem Cell Research Center at UCLA, Los Angeles, CA, USA


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As newer immunotherapies are developed, the necessity to non-invasively and temporally assess the changes in the immune system will be more important. Currently, a variety of cytokine therapies, vaccines, adoptive cellular therapy, and immunoregulatory antibodies are being advanced in the preclinical and clinical arenas. These developments highlight the necessity to use non-invasive imaging techniques to follow the therapeutic site of action, duration of immune response and the response of the tumor. Positron emission tomography (PET) imaging has emerged as a flexible tool which allows the user to assess multiple aspects of the immune response, including the ability to monitor the primary and secondary immune response, particular effector subpopulations of the immune response, and with novel probes, to more selectively monitor the immune response versus the tumor. This review focuses on the use of PET imaging to monitor the dynamic, multicellular and distinct spatiotemporal aspects of immunotherapy for malignancy.

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asingh@mednet.ucla.edu