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A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
Online ISSN 1827-1936
LATEST ADVANCES IN RADIOPHARMACOLOGY AND RADIOPHARMACY 2009
Domènech A. 1, Benítez A. 1, Bajén M. T. 1, Ricart Y. 1, Rodríguez-Gasén A. 1, Palacín J. A. 2, Català I. 3, Gil M. 4, Pernas S. 4, García A. 5, Martín-Comín J. 1
1 Department of Nuclear Medicine, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain;
2 Department of Plastic Surgery, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain;
3 Department of Pathology, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain;
4 Department of Oncology, Catalan Institute of Oncology-IDIBELL, Barcelona, Spain;
5 Department of Gynecology, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain
AIM:. To determine whether preoperative factors, such as size of metastases in the sentinel lymph node (SLN), number of positive SLNs (1, >1), tumoral grade, lymphovascular invasion (LVI) and tumoral size can predict the presence of metastases in non-SLNs, when the SLN is positive-.
METHODS:The study population was 1 146 breast cancer patients. Lymphadenectomy was performed in 150. Three groups of patients were established depending on the size of the metastases in SLNs: group A: <2 mm; group B: 2 ≤GC ≤5 mm; group C: >5 mm. Either the c2 test or Fisher’s test was performed to compare categorical variables, and a multivariate conditional logistic regression model for data sets was performed to identify the deterministic factors of metastases presence.
RESULTS:Ten percent of group A, 28% of group B and 52% of group C presented non-SLN metastases. Patients with >1 positive-SLN presented significantly more non-SLN metastases than those with only one positive-SLN; 56% of patients with LVI presented non-SLN metastases versus 26% of those without LVI. The tumoral grade and size did not seem to have any influence on the number of patients with non-SLN metastases. The number of positive-SLNs and size of metastases were statistically associated with the presence of metastases.
CONCLUSIONS. In this study population, the probability of finding non-SLN metastases was statistically related to the size of the SLN metastases and the number of positive-SLNs.