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CURRENT ISSUETHE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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FOREWORD  NON-STANDARD PET NUCLIDES


The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2008 June;52(2):185-92

language: English

Cross-bridged macrocyclic chelators for stable complexation of copper radionuclides for PET imaging

Anderson C. J. 1, Wadas T. J. 1, Wong E. H. 2, Weisman G. R. 2

1 Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis, MO, USA
2 Department of Chemistry University of New Hampshire, Durham, NH, USA


FULL TEXT  REPRINTS


Copper-64 (t1/2=12.7 h; β+: 17.4%; Eβ+max=656 keV; β-: 39%; Eβ-max=573 keV) has emerged as an important non-standard positron-emitting radionuclide for positron emission tomography imaging of diseased tissues. A significant challenge of working with copper radionuclides is that they must be delivered to the living system as a stable complex that is attached to a biological targeting molecule for effective imaging and therapy. Significant research has been devoted to the development of ligands that can stably chelate 64Cu, in particular, the cross-bridged (CB) macrocyclic chelators. This review describes the coordination chemistry and biological behavior of 64Cu-labeled CB complexes.Copper-64 (t1/2=12.7 h; β+: 17.4%; Eβ+max=656 keV; β-: 39%; Eβ-max=573 keV) has emerged as an important non-standard positron-emitting radionuclide for positron emission tomography imaging of diseased tissues. A significant challenge of working with copper radionuclides is that they must be delivered to the living system as a stable complex that is attached to a biological targeting molecule for effective imaging and therapy. Significant research has been devoted to the development of ligands that can stably chelate 64Cu, in particular, the cross-bridged (CB) macrocyclic chelators. This review describes the coordination chemistry and biological behavior of 64Cu-labeled CB complexes.

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