Home > Journals > The Quarterly Journal of Nuclear Medicine and Molecular Imaging > Past Issues > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2005 March;49(1) > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2005 March;49(1):106-115

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,481


eTOC

 

REVIEW ARTICLES  NUCLEAR CARDIOLOGY: THE PRESENT AND THE FUTURE
Guest Editors: R. Sciagrà and J. J. Bax
FREEfree


The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2005 March;49(1):106-115

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Molecular imaging. A new approach to nuclear cardiology

Dobrucki L. W., Sinusas A. J.

Section of Cardiovascular Medicine Department of Internal Medicine Yale University School of Medicine, New Haven, CT, USA


FULL TEXT  


Nuclear cardiology has historically played an important role in detection of cardiovascular disease as well as risk stratification. With the growth of molecular biology have come new therapeutic interventions and the requirement for new diagnostic imaging ap-proaches. Noninvasive targeted radiotracer based as well as transporter gene imaging strategies are evolving to meet these new needs, but require the development of an interdisciplinary approach which focuses on molecular processes, as well as the pathogenesis and progression of disease. This progress has been made possible with the availability of transgenic animal models along with many technological advances. Future adaptations of the developing experimental procedures and instrumentation will allow for the smooth translation and application to clinical practice. This review is intended as a brief overview on the subject molecular imaging. Basic concepts and historical perspective of molecular imaging will be reviewed first, followed by description of current technology, and concluding with current applications in cardiology. The emphasis will be on the use of both single photon emission computed tomography (SPECT) and positron emission tomography (PET) radiotracers, although other imaging modalities will be also briefly discussed. The specific approaches presented here will include receptor-based and reporter gene imaging of natural and therapeutic angiogenesis.

top of page

Publication History

Cite this article as

Corresponding author e-mail