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CURRENT ISSUETHE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Journal on Nuclear Medicine and Molecular Imaging

A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413

Frequency: Quarterly

ISSN 1824-4785

Online ISSN 1827-1936

 

The Quarterly Journal of Nuclear Medicine 2003 December;47(4):270-8

USE OF RADIOLABELLED PEPTIDES FOR SCINTIGRAPHY IN NON-ONCOLOGIC DISEASES 

The role of octreotide scintigraphy in rheumatoid arthritis and sarcoidosis

Dalm V. A. S. H. 1, Van Hagen P. M. 1, Krenning E. P. 1,2

1 Department of Internal Medicine Erasmus MC Rotterdam, The Netherlands
2 Department of Nuclear Medicine Erasmus MC Rottherdam, The Netherlands

Somatostatin recep­tors are wide­ly ­expressed on ­cells and tis­sues through­out the ­human ­body. Apart ­from ­their expres­sion in the phys­io­log­i­cal tar­get ­organs of the pep­tide, som­a­tos­ta­tin recep­tors are ­also ­expressed in var­i­ous ­tumours. The expres­sion of som­a­tos­ta­tin recep­tors on neu­ro­en­do­crine ­tumours led to the devel­op­ment of som­a­tos­ta­tin recep­tor scin­tig­ra­phy ­using [111In-­DTPA-D-Phe1]-octre­o­tide (111In-pen­tet­re­o­tide) in ­order to vis­u­al­ize som­a­tos­ta­tin recep­tor pos­i­tive ­tumours and ­their metas­ta­ses in ­vivo. Previous stud­ies report­ed the expres­sion of som­a­tos­ta­tin recep­tors in ­both nor­mal and path­o­log­i­cal ­cells and tis­sues of the ­human ­immune ­system as ­well. Somatostatin recep­tors ­have ­been dem­on­strat­ed in Hodgkin’s and non-Hodgkin’s lym­pho­mas and sst scin­tig­ra­phy has ­shown to be a use­ful ­tool in diag­no­sis and stag­ing of ­these dis­eas­es. Moreover, sst expres­sion has ­also ­been detect­ed in gra­nu­lo­ma­teus dis­eas­es, ­like sar­coi­do­sis and ­auto-­immune dis­eas­es, ­like rheu­ma­toid ­arthritis. In ­this ­paper we dis­cuss the (pos­sible) ­role of som­a­tos­ta­tin recep­tor scin­tig­ra­phy in diag­no­sis, stag­ing or fol­low-up of ­patients suf­fer­ing ­from sar­coi­do­sis and rheu­ma­toid ­arthritis.

language: English


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