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Vavere A. L. 1,2, Lewis J. S. 2,3
1 Department of Chemistry Washington University School of Medicine, St. Louis, MO, USA
2 Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO, USA
3 Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
It is clear that various imaging modalities have given keen insight into the molecular mechanisms involved in anti-angiogenic treatments. A key to the advancement of anti-angiogenic therapy is not only the discovery of new drugs and treatments, but the analysis of the specific modes of action of these compounds in order to produce the next generation with greater effectiveness. While existing clinical methods incorporate the analysis of serum and urine to measure angiogenic factors, an imaging technique monitoring the effectiveness of anti-angiogenic therapy would be a convenient, noninvasive, cost effective technique to aid in treatment planning and disease management.