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A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
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The Quarterly Journal of Nuclear Medicine 2001 December;45(4):294-301

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Current role of lung scintigraphy in pulmonary embolism

Giordano A., Angiolillo D. J.

From the Institute of Nuclear Medicine and *Institute of Cardiology Università Cattolica del S. Cuore “A. Gemelli”, Rome, Italy


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The piv­otal ­role of ­lung scin­tig­raphy in the diag­nosis of pul­mo­nary embo­lism (PE) has ­been ques­tioned in ­recent ­years due to the intro­duc­tion of ­spiral com­puted tomog­raphy. How­ever, the scin­ti­graphic ­results ­used for com­par­i­sons are ­often ­those of the author­i­ta­tive ­PIOPED ­(Prospective Investigation of Pulmonary Embolism Diagnosis) study, car­ried out in the 1980s. Pul­mo­nary scin­tig­raphy has pro­gressed ­from ­those ­years ­both in the method­o­log­ical and inter­pre­ta­tive ­fields, ­although per­haps too ­slowly. ­Results ­better ­than ­those of ­PIOPED’s ­have ­been pre­sented by ­study ­groups who ­used: 1) per­fu­sion-­only ­approach, 2) ­SPET ­imaging; 3) new inter­pre­ta­tive cri­teria; 4) dif­ferent pre­dic­tion ­rules to inte­grate clin­ical and scin­ti­graphic prob­abil­ities of PE. ­These ­advances are ­still insuf­fi­ciently rec­og­nised by the ­nuclear med­i­cine com­mu­nity, pos­sibly due to a ­sort of ­PIOPED-­based “cul­tural glo­bal­isa­tion”. ­This ­paper ­reviews the ­actual advan­tages and lim­i­ta­tions of ­nuclear med­i­cine tech­niques, the diag­nostic ­role of scin­tig­raphy ­within the diag­nostic algo­rithms pro­posed by inter­na­tional ­working ­groups and sci­en­tific soci­eties and the ­results ­obtained ­from ­SPET ­imaging in the diag­nosis of PE.

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