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CURRENT ISSUETHE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
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The Quarterly Journal of Nuclear Medicine 2001 March;45(1):84-90

NUCLEAR MEDICINE APPLICATIONS FOR BONE METASTASES 

186Re-Etidronate. Efficacy of palliative radionuclide therapy for painful bone metastases

Han S. H., De Klerk J. M. H., Zonnenberg B. A. *, Tan S., Van Rijk P. P.

From the Department of Nuclear Med­i­cine
*Oncology Section, Department of Internal Medicine, University Medical Center Utrecht, The Netherlands

Pain pal­li­a­tion ­with ­bone-seek­ing radio­phar­ma­ceu­ti­cals is an effec­tive treat­ment modal­ity in ­patients ­with ­advanced met­a­stat­ic ­bone can­cer. Several stud­ies ­have ­shown encour­ag­ing clin­i­cal ­results of pal­li­a­tive ther­a­py ­using 186Re-­HEDP, ­with an over­all report­ed ­response ­rate of ±71% for pain­ful ­osseous metas­ta­sized pros­tate and ­breast can­cer ­patients. 186Re-­HEDP is a ­very poten­tial iso­tope ­with numer­ous advan­ta­geous char­ac­ter­is­tics for ­this pur­pose. Myelosuppressive tox­ic­ity is lim­it­ed and rever­sible, ­which ­makes repet­i­tive treat­ment ­safe. However, indi­vid­u­al stud­ies are dif­fi­cult to com­pare, and are ham­pered by the numer­ous and dif­fer­ent meth­ods ­used to ­assess clin­i­cal ­respons. Standardized clin­i­cal ­response assess­ment ­using the objec­tive mul­ti-dimen­sion­al ­pain eval­u­a­tion mod­el ­should there­fore be imple­ment­ed.

language: English


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