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A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
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  NUCLEAR MEDICINE APPLICATIONS FOR BONE METASTASES


The Quarterly Journal of Nuclear Medicine 2001 March;45(1):53-64

language: English

Radiological imaging for the diagnosis of bone metastases

Rybak L. D., Rosenthal D. I.

From the Department of Radiology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA


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Primary neo­plasms of the skele­ton are ­rare, but met­a­stat­ic involve­ment is, unfor­tu­nate­ly, a com­mon occur­rence. This is par­tic­u­lar­ly ­true for cer­tain pri­mary ­tumors. Skeletal metas­ta­ses are clin­i­cal­ly sig­nif­i­cant ­because of asso­ciat­ed symp­toms, com­pli­ca­tions ­such as path­o­log­i­cal frac­ture and ­their pro­found sig­nif­i­cance for stag­ing, treat­ment and prog­no­sis.
Detection of ­bone metas­ta­ses is, ­thus, an impor­tant ­part of treat­ment plan­ning. The fre­quen­cy ­with ­which metas­ta­ses are detect­ed var­ies con­sid­er­ably ­with the ­type of pri­mary ­tumor and ­with the meth­o­dol­o­gy uti­lized for detec­tion.
Four ­main modal­ities are uti­lized clin­i­cal­ly: ­plain ­film radiog­ra­phy, CT ­scan, nucle­ar imag­ing and mag­net­ic res­o­nance imag­ing. In ­this dis­cus­sion, we ­will ­review lit­er­a­ture on the radiol­o­gy of skel­e­tal metas­ta­ses ­with ­respect to ­lesion detec­tion, assess­ment of ­response to treat­ment and pos­sible ther­a­peu­tic impli­ca­tions. The ­bulk of the dis­cus­sion ­will ­focus on MRI and nucle­ar stud­ies ­since ­most of the ­recent advanc­es ­have ­been ­made in ­these are­as.

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