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A Journal on Nuclear Medicine and Molecular Imaging
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The Quarterly Journal of Nuclear Medicine 2000 December;44(4):347-54

language: English

Genetic susceptibility to radiations. Which impact on medical practice?

Alapetite C., Cosset J. M., Bourguignon M. H. *, Masse R. *

From the Department of Radiotherapy Curie Institute, Paris, France
*Office de Protection con­tre les Rayonnements Ionisants Le Vésinet, France


FULL TEXT  


Recent ­progress espe­cial­ly in the ­field of ­gene iden­tifi­ca­tion and expres­sion ­have ­raised ­more atten­tion on genet­ic sus­cep­ti­bil­ity to can­cer pos­sibly ­enhanced by radi­a­tion. Radiation ther­a­pists are most­ly con­cerned by ­this ques­tion ­since hyper­sen­si­tive ­patients may suf­fer ­from ­adverse ­effects in nor­mal tis­sues fol­low­ing a stan­dard radi­a­tion ther­a­py and nor­mal­ly sen­si­tive ­patients ­could ben­e­fit ­from high­er dos­es of radi­a­tion for bet­ter treat­ment of ­their malig­nant ­tumors. Although ­only a ­small per­cent­age of indi­vid­u­als are « hyper­sen­si­tive » to radi­a­tion ­effects, all med­i­cal spe­cial­ists ­using ion­is­ing radi­a­tion ­should be ­aware of ­this new ­progress in med­i­cal knowl­edge. The ­present ­paper ­reviews the ­main pathol­o­gies (dis­eas­es, syn­dromes…) ­known or strong­ly sus­pect­ed to be asso­ciat­ed ­with a hyper­sen­si­tiv­ity to ion­iz­ing radi­a­tion. Then the ­main ­tests ­capable of detect­ing in ­advance ­such pathol­o­gies are ana­lyzed and com­pared. Finally guide­lines are pro­vid­ed, espe­cial­ly to the radi­a­tion ther­a­pists to lim­it the ­risk of ­severe com­pli­ca­tions (or ­even ­deaths) for ­this spe­cif­ic sub­set of ­patients suf­fer­ing ­from a genet­ic dis­or­der ­with a sus­cep­ti­bil­ity to radi­a­tions.

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