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A Journal on Nuclear Medicine and Molecular Imaging
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  IMAGING INFECTION


The Quarterly Journal of Nuclear Medicine 1999 March;43(1):38-45

language: English

The clin­i­cal ­role of nucle­ar med­i­cine in rheu­ma­toid ­arthritis ­patients. A com­par­i­son ­with oth­er diag­nos­tic imag­ing modal­ities

Vos K., Van Den Linden E.*, Pauwels E. K. J.* **

From the Departments of Rheumatology *Radiology and **Division of Nuclear Medicine Leiden University Medical Centre, The Netherlands


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In ­patients ­with rheumatoid arthritis (RA) syn­ovitis activ­ity is the dom­i­nant clin­i­cal var­i­able ­that deter­mines the ther­a­peu­tic ­approach. At ­present, the ­amount of pain­ful and swol­len ­joints ­assessed by phys­i­cal exam­ina­tion, is gen­er­al­ly ­used to meas­ure the ­degree of syn­ovitis activ­ity. A ­gold stan­dard for the assess­ment of syn­ovitis activ­ity is not avail­able. The avail­abil­ity of an objec­tive and repro­du­cible meth­od to eval­u­ate syn­ovitis activ­ity in RA ­would be of ­great val­ue in ­patient man­age­ment and in exam­ina­tion of ther­a­peu­tic ­effects. An advan­tage of the use of radio­phar­ma­ceu­ti­cals in detec­tion of ­arthritis activ­ity, com­pared ­with oth­er imag­ing tech­niques, is the pos­sibil­ity to depi­ct all ­joints in a sin­gle ­image. Furthermore the tech­nique may ­image ­joints ­which are dif­fi­cult to ­assess clin­i­cal­ly or radio­graph­i­cal­ly and may ­also ­detect ­joint inflam­ma­tion in an ear­ly ­phase. In ­this over­view dif­fer­ent scin­ti­graph­ic tech­niques are com­pared ­with ­each oth­er and ­with oth­er diag­nos­tic imag­ing modal­ities.

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