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A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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  IMAGING INFECTION


The Quarterly Journal of Nuclear Medicine 1999 March;43(1):21-8

language: English

Imaging tech­niques for eval­u­a­tion of post­op­er­a­tive ortho­pedic infec­tions

Seabold J. E., Nepola J. V.

From the Depart­ments of ­Radiology Divi­sion of ­Nuclear Med­i­cine and Ortho­pedic Sur­gery Uni­ver­sity of ­Iowa Col­lege of Med­i­cine Iowa ­City, ­Iowa, USA


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Labeled leu­ko­cyte scin­tig­raphy is the pre­ferred ­imaging tech­nique for the eval­u­a­tion of sus­pected post­op­er­a­tive ortho­pedic infec­tions. ­Labeled leu­ko­cyte local­iza­tion ­returns to a ­normal pat­tern ­faster ­than MRI ­after ­bone ­trauma, sur­gical pro­ce­dures, and treat­ment of osteo­my­e­litis. 99mTc ­HMPAO ­labeled leu­ko­cyte scin­tig­raphy is ­useful, par­tic­u­larly in chil­dren, ­because ­less periph­eral ­blood ­volume is ­required for ­labeling. How­ever, ­delayed 16-20 ­hour ­imaging is usu­ally ­needed to ­detect low-­grade osteo­my­e­litis, and 111In WBC usu­ally pro­vides ­better ­images in ­adults. Com­bined 111In WBC/99mTc ­sulfur col­loid ­marrow ­images ­improve the spec­i­ficity for detec­tion of osteo­my­e­litis in ­regions con­taining ­active ­bone ­marrow. Simul­ta­neous 111In leu­ko­cyte/99mTc ­bone ­SPECT ­imaging is usu­ally nec­es­sary in ­regions ­such as the ­skull, ­spine, and ­hips, ­where ­there is over­lap­ping ­bone, and ­soft tis­sues.

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