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A Journal on Nuclear Medicine and Molecular Imaging
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The Quarterly Journal of Nuclear Medicine 1998 September;42(3):199-210

language: English

Neuropharmacological imaging in epilepsy with PET and SPECT

Henry T. R., Pennell P. B.

From the ­Emory Epi­lepsy ­Center, Depart­ment of Neu­rology Emory Uni­ver­sity ­School of Med­i­cine, ­Atlanta, USA


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Func­tional neu­ro­im­aging ­with posi­tron and ­single ­photon ­emitter-­labeling has ­added con­sid­er­ably to the under­standing of epi­leptic sei­zure ­activity and of the post­ictal and inter­ictal cere­bral dys­func­tions ­that accom­pany ­many epi­lep­sies. ­Some of ­these func­tional alter­a­tions ­cannot be ­studied in ­humans by any ­other tech­nique, and in ­other ­instances the infor­ma­tion is com­ple­men­tary to ­that pro­vided by ­other tech­niques, ­some of ­which are inva­sive or ­even ­require ­tissue destruc­tion. Avail­able radio­tracer ­imaging tech­niques ­have yet to be ­fully ­applied to sev­eral impor­tant epi­leptic syn­dromes (­including the ­Lennox-Gas­taut syn­drome and ­other sec­on­dary gen­er­al­ized epi­lep­sies), to phys­io­log­ical ­aspects of the nat­ural his­tory of tem­poral ­lobe epi­lepsy or any ­other com­monly occur­ring epi­lepsy, and to the assess­ment of mech­a­nisms of ­action and ­adverse ­effects of anti­epi­leptic ­drugs and ­other epi­lepsy ther­a­pies. New radio­tracers ­should be devel­oped to ­permit ­study of spe­cific excit­a­tory ­amino ­acid recep­tors and ­other ­receptor ­sites ­that are ­known to be rel­e­vant to the devel­op­ment of epi­lepsy, to the ­onset of indi­vidual sei­zures, and to inter­ictal dys­func­tions.

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