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JOURNAL OF NEUROSURGICAL SCIENCES

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Journal of Neurosurgical Sciences 2017 May 31

DOI: 10.23736/S0390-5616.17.04052-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Effects of magnetically controlled growing rods surgery on pulmonary function in young subjects with spinal muscular atrophy type 2 and other neuromuscular scoliosis

Luca COLOMBO 1, Carlotta MARTINI 1, Chiara BERSANINI 2, Francesca IZZO 2, Jorge H., VILLAFAÑE 3, Pedro BERJANO 1, Claudio LAMARTINA 1

1 IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; 2 Ospedale dei Bambini “Vittore Buzzi”, Milan, Italy; 3 IRCCS Don Gnocchi Foundation, Milan, Italy


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BACKGROUND: The aim of this study was to determine the effects of magnetically controlled growing rods surgery (MCGRS) of the scoliosis on pulmonary function in children with neuromuscular scoliosis.
METHODS: Seven patients, 85.7% female (mean ± SD age: 6.7±1.2 years), with neuromuscular scoliosis (4 SMA II, 2 congenital myopathies and 1 VACTER syndrome), received MCGRS of the spine in the thoraco-lumbar area. The outcome measures were clinical features and pulmonary function (forced vital capacity [FVC] and forced expiratory volume in 1st second [FEV1], were collected. All measures were collected at pre-, post-intervention and follow-up (short-term [0–6 months], mid-term [7–12 months], and long-term [13-24 months]).
RESULTS: MCGRS reduced Cobb angle after intervention in 100% in subjects and this result was maintained at 24-month follow-up (all, P=0.001). There was no significant difference in FVC or FEV1 between preoperative and each postoperative period, (P>0.05). Analyses of the correlation coefficients indicated no significant associations between changes in pulmonary function and scoliosis.
CONCLUSIONS: The current study found that MCGRS addressed to the scoliosis maintained pulmonary function during long-term follow-up; However, pulmonary function was not associated with scoiosis in children with neuromuscular scoliosis.


KEY WORDS: Congenital muscular dystrophy - Spinal muscular atrophy - Muscular dystrophy - SMA II - Pulmonary function - Scoliosis

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