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JOURNAL OF NEUROSURGICAL SCIENCES
A Journal on Neurosurgery
Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651
Journal of Neurosurgical Sciences 2016 Sep 07
LINAC-Based radiosurgery for melanoma, sarcoma and renal cell carcinoma brain metastases
Ernesto MARANZANO, Michelina CASALE, Rossella RISPOLI, Fabio TRIPPA, Lorena DRAGHINI, Fabio ARCIDIACONO, Sandro CARLETTI, Paola ANSELMO ✉
Radiotherapy Oncology Centre, "S. Maria" Hospital, Terni, Italy
BACKGROUND: To report response, overall survival (OS) and toxicity in patients with radioresistant brain metastases (BM) treated with radiosurgery (SRS).
METHODS: Patients with renal cell carcinoma, melanoma and sarcoma with one to four brain metastases received SRS without whole brain radiotherapy.
RESULTS: 50 patients with 77 BM were treated. 46 (92%) patients with 71 BM were evaluable. Median follow-up was 67 months and median OS 11.8 months. At the time of analysis all patients had died. Brain control was conditioned by response to SRS (P<0.0001), while OS by histology (renal cell carcinoma versus melanoma and sarcoma) (P=0.04) and status of the tumour outside the brain (P=0.05). Treatment was well tolerated without more than grade 2 acute toxicity.
CONCLUSIONS: Treatment of BM from radioresistant tumors with SRS assures good brain control and OS with low toxicity. Our data suggest a better prognosis associated to renal cell carcinoma histology.