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Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651
Online ISSN 1827-1855
Vijay M. RAVINDRA 1, Jian GUAN 1, Christopher M. HOLLAND 1, Andrew T. DAILEY 1, Meic H. SCHMIDT 1, Jakub GODZIK 2, Robert S. HOOD 1, Wilson Z. RAY 3, Erica F. BISSON 1
1 Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah; 2 Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona; 3 Department of Neurosurgery, Washington University in St. Louis, St. Louis, Missouri
BACKGROUND: Patients undergoing elective spinal fusion have an alarming rate of vitamin D deficiency, but its impact on bone fusion and patient outcomes is unclear. We investigated the association of perioperative vitamin D levels, fusion rates, and patient- reported outcome in patients undergoing spinal fusion for cervical spondylotic myelopathy.
METHODS: In this one-year, prospective, single-center observational study, serum 25- OH vitamin D levels were measured perioperatively in adult patients. Serum vitamin D levels <30 ng/mL were considered abnormal. The primary outcome measures were postoperative patient-reported outcomes (Neck Disability Index, Visual Analog Scale, EuroQol EQ-5D-3L, EQ-VAS). Secondary outcome measures were the presence of and time to solid bony fusion, controlling for body mass index, age, and number of motion segments.
RESULTS: Forty-one of 58 patients (71%) had laboratory-confirmed abnormal vitamin D levels. Patients with low vitamin D were younger (p<0.05) and had a higher BMI (p<0.05) than patients with adequate vitamin D, but the groups were otherwise similar. There were no differences in mean time to fusion between the two groups, but patients with low vitamin D reported more postoperative disability (p<0.05). Multivariate model analysis demonstrated an independent, significant association between normal vitamin D and lower postoperative neck disability index (p=0.05) and EQ-5D-3L (p=0.03).
CONCLUSIONS: Vitamin D deficiency (<30 ng/mL) is highly prevalent in patients undergoing elective spinal fusion for cervical myelopathy. Low vitamin D levels were associated with worse patient-reported outcomes and were an independent predictor of greater disability, which suggests vitamin D supplementation may offer some benefit in these patients.