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A Journal on Neurosurgery

Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651

Frequency: Quarterly

ISSN 0390-5616

Online ISSN 1827-1855


Journal of Neurosurgical Sciences 2015 May 20

A review of recent advances in neuroimaging of frontotemporal lobar degeneration

D’Agata F. 1, Orsi L. 2, Cicerale A. 1, Rubino E. 3, Rainero I. 2, 3, Bergui M. 1, 4, Pinessi L. 2, 3

1 LabNI, Department of Neuroscience, University of Turin, Italy;
2 Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza, Turin, Italy;
3 Department of Neuroscience, Neurology Section, University of Turin, Turin, Italy;
4 Department of Neuroscience, Neuroradiology Section, AOU Città della Salute e della Scienza, Turin, Italy

BACKGROUNDS: The terms frontotemporal lobar degeneration (FTLD) indicate a large set of neurodegenerative diseases, heterogeneous in their genetic, pathologic and clinical aspects.
OBJECTIVES: This review will focus on the most recent contribution of neuroimaging tools on the diagnosis, characterization and pathogenesis of FTLD.
DATA SOURCES: PubMed, Scopus, Ovid.
STUDY ELIGIBILITY CRITERIA: recent papers published in English in the last 3 years.
RESULTS: We found 91 papers of interest and reviewed their contents, finding in particular 4 major topics: the contribution of neuroimaging on the differential diagnosis; patients’ functional characterization; new neuroimaging tools under development and presymptomatic genetic forms.
CONCLUSIONS: Neuroimaging techniques have shown to be useful supporting tools in diagnosis, even if not always determinant to reach a conclusive decision, and quite important to identify phenocopies. At the moment there is not a neuroimaging biomarker that could track the progressive course of dementias and the effect of therapies, but it is possible that in the future Diffusion Tensor Imaging and molecular imaging could fill this void. Monitoring in vivo the evolution of the pathology for at least 5 years is essential, which would only be possible in a large multi centric study, while asymptomatic forms would require even longer observation periods.

language: English


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