Advanced Search

Home > Journals > Journal of Neurosurgical Sciences > Past Issues > Articles online first > Journal of Neurosurgical Sciences 2015 Apr 17

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEJOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery

Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651

Frequency: Quarterly

ISSN 0390-5616

Online ISSN 1827-1855

 

Journal of Neurosurgical Sciences 2015 Apr 17

Minimally invasive Motor Cortex stimulation for Parkinson’s disease: a review of literature

Lavano A., Guzzi G., De Rose M., Romano M., Della Torre A., Vescio G., Deodato F., Lavano F., Volpentesta G.

Department of Neurosurgery, University “Magna Graecia”, Catanzaro, Italy

Extra/intradural strip electrode implantation on Motor Cortex may be possible minimally invasive neurosurgical method for therapeutic neuromodulation in Parkinson’s disease . The aim of this review is to assess Motor Cortex Stimulation (MCS) efficacy and safety in advanced Parkinson’s disease. 16 published articles were included with a total of 130 PD patients treated. In almost all results are from prospective observational open labeled study, only in two studies blinded assessment was carried out. Negative results are reported in three studies. Significant improvement in motor symptoms with remarkable effect on axial symptoms, L‐dopa induced dyskinesias and QoL are outlined in thirteen studies. Surgical technique involved implant of four‐contact strip electrode over M1 in epidural space with exception of few cases in which implant was carried out in subdural space. Surgical procedure was performed contralateral to most affected side with exception of five patients in which it was carried at dominant hemisphere; in four patients electrode implant was bilateral but stimulation was carried out simultaneously on both sides only in two cases. Complications and adverse events occurred very rarely for extradural MCS whereas with higher rate for subdural MCS. Based on review of current literature extra/intradural Motor Cortex Stimulation represents an alternative to DBS for surgically treating PD patients who are not candidate for DBS. MCS is a minimally invasive neuromodulation procedure with low morbidity‐mortality that can relieve all three major symptoms of PD on both sides simultaneously and bilaterally; it has significant effectiveness on axial symptoms, gait disturbances and therapy complications.

language: English


FULL TEXT  REPRINTS

top of page