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Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651
Online ISSN 1827-1855
Munivenkatappa A. 1, Devi B. I. 2, Shukla D. P. 2, Rajeswaran J. 3
1 Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Bangalore, India;
2 Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India;
3 Department of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bangalore, India
AIM: Diffusion tensor imaging (DTI) is an advanced and sensitive technique that detects sub-threshold pathology in normal imaging brain injury patients. Currently, there are no 3time-point studies that have considered DTI technique among these patients. The present study has investigated 3time-point DTI imaging and its association with cognitive deficits.
METHODS: Twenty-one patients were available for MRI and neuropsychological test (NPT) assessment for all the 3timepoints. Initially (<36hours), all patients presented with GCS 15 and normal scan findings. The DTI (p<0.0001) and NPT scores (p<0.05) were analyzed using repeated-measure of analysis. The tensor values were correlated with specific time-point NPT scores using partial correlation (0.05).
RESULTS: Right cerebral-hemisphere showed significant alterations in both anisotropy and diffusivity values overtime. Cingulate-gyrus and occipital-lobe showed prominent changes in anisotropy value. Significant improvement in thalamo-cortical anisotropy value after 3-4months after injury was seen. The changes in diffusivity values were majorly seen in
frontal, parietal lobe, right inferior fronto-occipital & superior longitudinal fasciculus, and posterior supramarginal gyrus. Eventual changes of tensor values of thalamus, frontal and temporal lobe had persistent and significant association with attention and learning/memory aspects.
CONCLUSION: The study’s findings suggest that DTI detects and observes natural-recovery of brain regions affected by sub-threshold force.