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JOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery


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Journal of Neurosurgical Sciences 2017 April;61(2):157-63

DOI: 10.23736/S0390-5616.16.03120-9

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

Prognostic factors for temporal lobe epilepsy surgery in a tertiary center

Rodrigo A. ROCHA DA CRUZ ADRY 1 , Lucas CROCIATI MEGUINS 1, Remo DE SANTANA DE TOMI 2, Rodrigo I. PONGELUPPI 2, Sebastião C. DA SILVA Jr 1, Gerardo M. DE ARAÚJO FILHO 3, Lúcia H. NEVES MARQUES 4

1 Neurosurgery Unit, Department of Neurological Sciences, São José do Rio Preto Hospital, São José do Rio Preto Faculty of Medicine, São José do Rio Preto, Brazil; 2 São José do Rio Preto Hospital, São José do Rio Preto Faculty of Medicine, São José do Rio Preto, Brazil; 3 Psychiatry Unit, Department of Medical Psychiatry and Psychology, São José do Rio Preto Hospital, São José do Rio Preto Faculty of Medicine, São José do Rio Preto, Brazil; 4 Neurology Unit, Department of Neurological Sciences, São José do Rio Preto Hospital, São José do Rio Preto Faculty of Medicine, São José do Rio Preto, Brazil


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BACKGROUND: Temporal lobe epilepsy (TLE) represents the most common type of partial epilepsy. Early age of onset, a history of febrile convulsions, epileptiform discharges on electroencephalography, duration of epilepsy, number of generalized seizures and severity of psychiatric disorders are possible prognostic factors in patients with mesial temporal sclerosis. The aim of this study is to review the findings of clinical research, semiotic, psychological, electrophysiological and neuroradiological, and to relate these findings with the prognosis of patients with TLE who underwent anteromedial temporal lobectomy (ATL).
METHODS: Of 1214 patients evaluated for surgery in the epilepsy Center of the São Jose do Rio Preto Faculty of Medicine (Faculdade de Medicina de São José do Rio Preto – FAMERP), a tertiary Brazilian epilepsy center, 459 underwent ATL for TLE. Exams and clinical data were analyzed and compared with Engel classification for outcome.
RESULTS: Of all the items analyzed, the MRI showed a greater influence on the outcome of patients and for clinical evaluation and pathological antecedents, age at surgery, the epilepsy duration, seizure frequency, mesial temporal sclerosis, dysplasia, perinatal insults, vascular insults, a family history of epilepsy, febrile seizures, neuropsychological abnormalities and presence of generalized tonic-clonic seizure has a statistical significance.
CONCLUSIONS: In order to identify the most appropriate candidates for ATL, it is very important to consider the prognostic factors associated with favorable for counseling patients in daily practice.


KEY WORDS: Temporal lobe epilepsy - Tonic-clonic epilepsy - Anterior temporal lobectomy - Prognosis

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Publication History

Issue published online: November 21, 2016
Article first published online: January 20, 2015
Manuscript accepted: January 8, 2015
Manuscript revised: December 15, 2014
Manuscript received: October 19, 2014

Cite this article as

Rocha da Cruz Adry RA, Crociati Meguins L, de Santana de Tomi R, Pongeluppi RI, da Silva Jr SC, de Araújo Filho GM, et al. Prognostic factors for temporal lobe epilepsy surgery in a tertiary center. J Neurosurg Sci 2017;61:157-63. DOI: 10.23736/S0390-5616.16.03120-9

Corresponding author e-mail

rodrigoadry@hotmail.com