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Home > Journals > Journal of Neurosurgical Sciences > Past Issues > Journal of Neurosurgical Sciences 2017 February;61(1) > Journal of Neurosurgical Sciences 2017 February;61(1):46-52

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CURRENT ISSUEJOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery

Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651

Frequency: Bi-Monthly

ISSN 0390-5616

Online ISSN 1827-1855

 

Journal of Neurosurgical Sciences 2017 February;61(1):46-52

    ORIGINAL ARTICLES

Dexmedetomidine could enhance surgical satisfaction in Trans-sphenoidal resection of pituitary adenoma

Alireza SALIMI 1, Guive SHARIFI 2, Houshang BAHRANI 1, Seyed A. MOHAJERANI 1,
Alireza JAFARI 3, Farhad SAFARI 1, Maryam JALESSI 4, Alireza MIRKHESHTI 5, Kamran MOTTAGHI 1

1 Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Loghman Hospital, Tehran, Iran; 2 Department of Neurosurgery, Shahid Beheshti University of Medical Sciences, Loghman Hospital, Tehran, Iran; 3 Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Labbafinejad Hospital, Tehran, Iran; 4 Endoscopic Pituitary and Skull Base Unit, ENT-Head and Neck Surgery Research Center and Department, Iran University of Medical Sciences, Rasool Akram Hospital, Tehran, Iran; 5 Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Emam Hossein Hospital, Tehran, Iran

BACKGROUND: Excessive bleeding is an unwanted complication of trans-sphenoidal resection of pituitary adenoma due to increases in intracranial pressure (ICP) and hemodynamic instability. Dexmedetomidine (Dex) anα2-agonists is the drug of choice in intensive care units (ICU) and cardiac surgeries to control abrupt changes in hemodynamic. Severe cardiovascular responses occur during trans-sphenoidal resection (TSR) of the pituitary adenoma despite adequate depth of anesthesia. The aim of this paper was to determine the effect of Dexmedetomidine on bleeding as primary outcome, and surgeon’s satisfaction and hemodynamic stability as secondary outcomes in patients undergoing trans-sphenoidal resection of pituitary adenoma.
METHODS: Total numbers of 60 patients between 18-65 years old and candidate for elective trans-sphenoidal resection of pituitary adenoma were randomLy allocated to two groups; Dexmedetomidine infusion (0.6µg/kg/hour) or normal saline infusion. Mean arterial pressure (MAP), heart rate (HR), dose of hypnotics and narcotics during surgery, bleeding, and surgeon’s satisfaction were recorded.
RESULTS: Propofol maintenance dose (µg/kg/min) and total Fentanyl use (µg) were significantly lower in Dex group compare to control group (P=0.01 and 0.003, respectively). Total bleeding amount during operation in Dex group was significantly lower than control group (P=0.012). Surgeon’s satisfaction was significantly higher in Dex group at the end of surgery. MAP and heart rate throughout surgery were significantly lower in Dex group compare to control group (P=0.001).
CONCLUSIONS: Dexmedetomidine infusion (0.6µg/kg/hour) could reduce bleeding and provide surgeon’s satisfaction during trans-sphenoidal resection of pituitary adenoma.

language: English


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