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Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651
Online ISSN 1827-1855
Damien FETTER 1, Stephane DERREY 2, Romain LEFAUCHEUR 1, Alaina BORDEN 1, David WALLON 1, Nathalie CHASTAN 3, David MALTETE 1, 4
1 Department of Neurology, Rouen University Hospital and University of Rouen, Rouen, France; 2 Department of Neurosurgery, Rouen University Hospital and University of Rouen, Rouen, France; 3 Laboratory of Neurophysiology, Rouen University Hospital and University of Rouen, Rouen, France; 4 INSERM U1079, Rouen Faculty of Medicine, Rouen, France
BACKGROUND: The aim of the present study was to assess the consequences of a simplification of the electrophysiological procedure on the post-operative clinical outcome after subthalamic nucleus implantation in Parkinson disease.
METHODS: Microelectrode recordings were performed on 5 parallel trajectories in group 1 and less than 5 trajectories in group 2. Clinical evaluations were performed 1 month before and 6 months after surgery.
RESULTS: After surgery, the UPDRS III score in the off-drug/on-stimulation and on-drug/on-stimulation conditions significantly improved by 66,9% and 82%, respectively in group 1, and by 65.8% and 82.3% in group 2 (P<0.05). Meanwhile, the total number of words (P<0.05) significantly decreased for fluency tasks in both groups. Motor disability improvement and medication reduction were similar in both groups.
CONCLUSIONS: Our results suggest that the electrophysiological procedure should be simplified as the team’s experience increases.