Advanced Search

Home > Journals > Journal of Neurosurgical Sciences > Past Issues > Journal of Neurosurgical Sciences 2016 March;60(1) > Journal of Neurosurgical Sciences 2016 March;60(1):18-20

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEJOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery

Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651

Frequency: Quarterly

ISSN 0390-5616

Online ISSN 1827-1855

 

Journal of Neurosurgical Sciences 2016 March;60(1):18-20

    ORIGINAL ARTICLES

Effect of minimally invasive surgery on the blood-brain barrier in patients with cerebral hemorrhage

Yang ZHANG, Wei A. CHEN

Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

BACKGROUND: This study aimed to evaluate the effect of minimally invasive aspiration of intracranial hematoma on blood brain barrier (BBB) and bleeding after secondary brain injury.
METHODS: The BBB index and levels of serum myelin basic protein were compared between patients treated conventionally (dehydration, improvement of brain metabolism, and other symptomatic treatment; N.=25) and those in whom minimally invasive aspiration of intracranial hematoma was performed 6-24 hours after the onset, in addition to conventional treatment (N.=25). Ten patients with diseases of non-central nervous system and normal cerebrospinal fluid tests who were hospitalized at the same period served as a normal control group.
RESULTS: The BBB index of patients treated with minimally invasive aspiration was significantly lower than that of conventionally treated group (P<0.05). Further, in both treatment groups BBB indexes were significantly higher than that of normal control group (P<0.01). Levels of myelin basic protein followed the same trend (P<0.05, minimally invasive aspiration vs. conventional treatment; P<0.01, both treatment groups vs. normal control group).
CONCLUSIONS: Permeability of BBB increases in patients with cerebral hemorrhage, as reflected by the increase in the BBB index and serum levels of myelin basic protein. Minimally invasive aspiration can reduce the injury to BBB and cerebral edema.

language: English


FULL TEXT  REPRINTS

top of page