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JOURNAL OF NEUROSURGICAL SCIENCES
A Journal on Neurosurgery
Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651
CONTROVERSIES AND UPDATES IN NEUROSURGERY
Journal of Neurosurgical Sciences 2011 December;55(4):297-304
Neurotransplantation: lux et veritas, fiction or reality?
Pendleton C. 1, Ahmed I. 2, Quinones-Hinojosa A. 1 ✉
1 Department of Neurosurgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD, USA;
2 Medical Scientist Training Program; Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Neurotransplantation remains a much-debated frontier in contemporary neurosurgery and neuroscience, with roots dating to the late 19th century. Contemporary applications are far-reaching, and ongoing laboratory research and clinical trials seek to define the mechanisms at play in neurotransplant engraftment and growth, while advancing the field forward into the 21st century. Neural transplantation therapy remains an attractive idea for treating central nervous system (CNS) and peripheral nervous system (PNS) pathologies. Phase I and phase II clinical trials assessing safety and efficacy are currently underway for various disorders. The remainder of this review will focus on ongoing clinical trials and more recent research advances involving neural transplantation therapy for neuronal death, axonal injury, peripheral nerve lesions, and cancer. The field of neural transplantation, while promising, is not without ethical and scientific dilemmas; this review will conclude with a discussion of the challenges researchers and clinicians face as the field of neural transplantation moves forward.