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Journal of Neurosurgical Sciences 2011 September;55(3):189-95

Copyright © 2011 EDIZIONI MINERVA MEDICA

language: English

An expandable prosthesis with dual cage-and-plate function in a single device for vertebral body replacement: the clinical experience on 14 consecutive cases with vertebral tumors

Ramírez J. J. 1, Ramírez J. J. Jr. 2, Chiquete E. 3, Gómez-Limón E. 4

1 Department of Orthopedics, Guadalajara “Fray Antonio Alcalde” Civil Hospital, Guadalajara University; Guadalajara, México; 2 Guadalajara Autonomous University, Zapopan, México; 3 Department of Internal Medicine, Guadalajara “Fray Antonio Alcalde” Civil Hospital Guadalajara University, Guadalajara, México: 4 Department of Neurology and Neurosurgery, Guadalajara “Fray Antonio Alcalde” Civil Hospital”, Guadalajara, University, Guadalajara, México


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AIM: The aim of this paper was to test the hypothesis that an expandable prosthesis with dual cage-and-plate function can provide immediate and durable spine stabilization after corpectomy.
METHODS:We designed an expandable vertebral body prosthesis with dual cage-and-plate function in a single device (JR-prosthesis). Anatomical studies were performed to design a titanium-made prosthesis. Cadaver assays were done with a stainless steal device to test fixation and adequacy to the human spine anatomy. Then, 14 patients with vertebral tumors (8 metastatic) underwent corpectomy and vertebral body replacement with the JR-prosthesis.
RESULTS:All patients had neurological deficit, severe pain and spine instability (mean follow-up: 25.4 months). Mean pain score before surgery in a visual analog scale improved from 7.6 to 3.0 points after operation (P=0.002). All patients achieved at least one grade of improvement in the Frankel score (P=0.003), excepting the 3 patients with Frankel grade A presurgery. Two patients with renal cell carcinoma died during the following 4 days after surgery (renal failure and massive bleeding), the rest attained a painless and stable spine immediately and maintained for long periods. No significant infections or implant failures were registered. A non-fatal case of inferior vena cava surgical injury was observed (repaired during surgery without further complications).
CONCLUSION:The JR-prosthesis stabilizes the spine immediately after surgery and for the rest of the patients’ life. To our knowledge, this is the first report on the clinical experience of any expandable vertebral body prosthesis with dual cage-and-plate function in a single device. These observations await confirmation in different scenarios.

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