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CURRENT ISSUEJOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery


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Journal of Neurosurgical Sciences 2004 March;48(1):37-41

 CASE REPORTS

Malignant prolactinoma: is metastasis a must? Clinico-pathologic and immunohistochemical study of a case

Vaishaya S., Tondon A.

Department of Neurosurgery All India Institute of Medical Sciences New Delhi, India

Pituitary car­ci­no­mas are ­rare ­tumors ­which ­have ­been con­ven­tion­al­ly ­defined as pri­mary ade­no­hy­poph­y­seal ­tumors ­with cere­bro­spi­nal or extra­cra­ni­al metas­ta­ses. According to the cur­rent cri­te­ria ­even a high­ly inva­sive ­tumor with­out metas­ta­ses is not con­sid­ered as malig­nant. A ­case of pitui­tary aden­o­ma is report­ed ­with an unprov­en ­site of metas­ta­sis but ­with rap­id ­increase in pro­lac­tin lev­els (35 000 ng/ml), show­ing exten­sive inva­sion on radiol­o­gy, and path­o­log­i­cal and immu­no­his­to­chem­i­cal stud­ies indi­cat­ing a high­ly mitot­ic varie­ty of ­tumor. On the ­basis of ­this ­case we ­want to empha­size ­that extra­cra­ni­al metas­ta­sis is not a ­must to ­label a pitui­tary aden­o­ma as a malig­nant ­tumor. Such aggres­sive behav­ior of the ­tumor and clin­i­co-path­o­log­i­cal ­course in ­itself ­should be suf­fi­cient for the ­tumor to be ­labeled as malig­nant.

language: English


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