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Journal of Neurosurgical Sciences 2003 June;47(2):113-6

language: English

Radiation-induced schwannomas of the nervous system. Report of five cases and review of the literature

Salvati M. 1, Polli F. M. 2, Caroli E. 2, Frati. A. 1, Missori P. 2, Delfini R. 2

1 Department of Neurosurgery, IRCCS INM Neuromed, Pozzilli (Isernia), Italy
2 Division of Neurosurgery, Department of Neurological Sciences, University of Rome “La Sapienza”, Rome, Italy


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Radiation ther­a­py has impor­tant ­delayed ­effects on the cen­tral ner­vous ­system. Prominent ­among ­these ­effects is radi­a­tion necro­sis of ner­vous tis­sue, but an onco­gen­ic ­effect is ­also rec­og­nized. Both ­benign and malig­nant intra­cra­ni­al ­tumors can devel­op in irra­di­at­ed ­fields, par­tic­u­lar­ly in chil­dren. Most of ­these ­tumors are sar­co­mas, menin­gio­mas or gli­o­mas and ­only occa­sion­al­ly schwan­no­mas. We ­report 5 cas­es of ­postirra­di­a­tion acous­tic ­nerve schwan­no­ma ­observed in our Department.

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